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Scale-Up Technology

DMC Biotechnologies completes ‘successful’ pilot of amino acid L-alanine in real world conditions.

DMC fermentors. ©DMC

“We recreate real life industrial conditions at BPF and help companies such as DMC validate their technology at pilot scale.”

US biotechnology company DMC Biotechnologies has announced that it has successfully produced its lead amino acid product, L-alanine at pilot scale.

DMC (@DmcBiotech) specialises in producing biochemicals using fermentation. Its product L-alanine is made by fermentation and is used in human nutrition and animal feed.

n a statement, DMC said that commercial key performance metrics were achieved and performance from the bench scale was also demonstrated at 3m3scale fermentation and for each of the downstream purification unit operations.

The robustness of DMC’s Dynamic Metabolic Control technology to the process environment was also validated, DMC added.

According to the DMC, the predictability of the DMC process has been demonstrated from high throughput screening to commercially relevant scale. Kilogram-sized samples of on-specification product are currently being provided to potential customers, paving the way to commercial launch later this year. No further strain improvement or process engineering is required.

During the execution of the fermentation, a technical failure of an inlet valve in the pilot plant resulted in a material deviation from the protocol.  This type of mechanical issue is commonplace in the real world of industrial fermentation.

The DMC strain and process were not materially affected by this deviation and the target metrics were still achieved because of the robustness of the technology and the timely response by Bioprocess Pilot Facility (BPF)’s operators.  In contrast, most of the current bioprocesses today would have been un-recoverable to this type of deviation.

Raimo van der Linden, Business Development Manager at Bioprocess Pilot Facility, said: “We recreate real life industrial conditions at BPF and help companies such as DMC validate their technology at pilot scale. The robustness of DMC’s process was thoroughly challenged during this work. The demonstration of robustness to the process environment is truly game-changing for the field of industrial biotechnology.”

Matt Lipscomb, Ph.D., CEO & Co-Founder of DMC, said: “Successful pilot scale production is an important step towards full commercialisation of L-alanine which will happen later this year. We knew our Dynamic Metabolic Control process was robust. It has been further proven through real-world operating conditions at BPF’s pilot plant.”

Speaking to Bio Market Insights last year, Lipscomb said that there was strong demand for amino acids in the animal and human nutrition markets. “However, the incumbent production routes are not able to provide them at a price point to enable broad adoption in the market. Customer discovery efforts have indicated that the market will grow rapidly if those amino acids can be provided at the target price point,” Lipscomb said.


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